Cytotoxicity of IL-2–expanded or DC-stimulated T cells against autologous CML targets. Autologous CML BMMNCs were incubated with various ratios of T cells stimulated with IL-2 alone (A) or IL-2 and DCs (B) for 6 hours, and the cell-free supernatants were assayed for LDH enzyme released. Maximum release was determined by lysing an equal number of target cells with 0.5% Triton X-100. Values were normalized for spontaneous release of enzyme by target and effector cells cultured alone. The symbols represent the results with individual patients. The data points shown were calculated using the mean value of triplicate cultures.