(A) Nucleotide acid sequences of the expressed Ig V_H genes from five cases of IgA and/or IgG isotype CLLs. In each cluster, the top amino acid sequences are given for comparison and represent those of the closest reported germline V_H gene. The letters below represent differences from the published germline genes. (B) Nucleic acid sequences of the rearranged D and J_H genes from five cases of IgA and/or IgG isotype CLL. Each sequence is compared to the known D and J_H sequences that have the greatest homology. Identity is indicated by a dot and differences are shown. Solid lines above each cluster depict the CDR sequences. These sequences are available from the EMBL/GenBank/DDBJ under accession numbers: U22381, U22387, U22388, U22389, U22390, and U22391.