Temporal dynamics of clonal fluctuation in mice reconstituted with peripheral blood mononuclear cells. Each horizontal lane represents the number of spleen colonies with a unique integration site. The size of the rectangle indicates the number of spleen colonies with the same unique marker; rectangles with symbols indicate the persistent clones; numbers in rectangles indicate unique clone identification number. (A) Three months after reconstitution; (B) 6 months after reconstitution; (C) 9 months after reconstitution; (D) 12 months after reconstitution. Y-axis, reconstituted animals; X-axis, number of individual colonies.