Effect of PKC downregulation on asexual and sexual stage parasite growth. (A) Asexual stage growth in normal (▪) and PKC-deficient (▴) RBCs. Each point represents the mean of triplicate counts ± SEM. This result is representative of four separate experiments. (B) Gametocyte production in normal (▪) and PKC-deficient (▴) cells. Gametocytemia is presented as a percentage of the total parasitemia, to allow for the effects of PKC downregulation on asexual stage growth. Each point represents the mean of triplicate counts ± SEM. This result is representative of four separate experiments.