Fig. 1.
Activation of ECs by thrombin or TRAP42-55. [Ca2+]i and PGI2 synthesis were measured as detailed in Materials and Methods from fura 2-loaded IVECs in suspension and from confluent HUVEC monolayers, respectively, stimulated with increasing concentrations of either thrombin (A) or TRAP42-55 (B). Each point is the mean ± SEM of at least three distinct experiments.