Fig. 2.
Inhibition by HLE and Cat G of Ca2+ mobilization induced by thrombin in ECs. [Ca2+]i was measured from fura 2-loaded IVECs preincubated for 5 minutes with increasing concentrations of HLE or Cat G before cell stimulation with 1 nmol/L thrombin. [Ca2+]i are expressed as the percentage of values measured on nontreated cells stimulated by thrombin. Basal [Ca2+]i was 177 ± 12 nmol/L (n = 7), and each histogram is the mean ± SEM of at least three distinct experiments.