CpG ODN and MoAb are more effective than MoAb alone in vivo at preventing death from tumor. Immunocompetent C3H mice were inoculated with 2,500 tumor cells IP on day 0. Therapy consisted of (▪) no ODN or MoAb, (▴) MoAb alone, (•) CpG ODN alone, or (○) CpG ODN and MoAb. CpG ODN (300 μg) was administered IP on day 2, and MoAb (50 μg) was administered on day 3. Each group contained 10 mice. Curves depict percent survival over 60 days. No mice living at day 60 developed tumor, and all survived more than 5 months. No toxicity was observed in any group.