Effects of infectious and inactivated viruses on LTB₄ and LTC₄ synthesis. Enriched monocyte suspensions (5 × 10⁶ cells/0.1 mL) were preincubated or not with infectious or inactivated viral particles for 30 minutes at 37°C and diluted 10-fold with HBSS before A23187 stimulation (75 nmol/L) for 5 minutes. Analyses of LTB₄ (A) and LTC₄ (B) contents of incubation media were performed as described in the Materials and Methods. Results are from one experiment (mean ± SD of triplicate incubations) and are representative of three separate experiments. UV/EBV, UV-irradiated EBV; HI/EBV, heat-inactivated EBV; EBV/72A1, EBV neutralized with the MoAb 72A1.