Radiographs of the femoral and tibial metaphyses of a child treated with deferoxamine therapy. Shown are the metaphyses prior to initiation of nightly subcutaneous deferoxamine (Fig 7A); 3 years after initiation of deferoxamine therapy (Fig 7B); and 6 years after initiation of deferoxamine therapy (Fig 7C). Radiographs show evidence of progressive widening and irregularity of the unossified metaphyseal matrix, which has irregular sclerotic margins. Similar processes in the proximal tibial metaphyses produced both varus and valgus deformities requiring bracing and osteotomy. (Reprinted with permission.144 )