Lateral view of the thoracic spine in an 11-year, 9-month-old girl with thalassemia major treated with intensive deferoxamine throughout childhood. The spine shows decreased vertebral height with intervertebral disc calcification, flattening and lengthening and anterior tapering or the vertebrae, wedging and moderate kyphosis in this region. Detailed inset shows a bone-within-bone appearance, demarcating a zone of pronounced calicification. (Reprinted by permission from Pediatric Radiology, Spinal deformities in deferoxamine-treated beta-thalassemia major patients, Hartkamp MJ, Babyn PS, Olivieri NF, Volume 23, pp 525-528, Figure 2, 1993, Copyright Springer-Verlag GmbH & Co, KG. 1993.)244