DA7-induced permeability. HUV-EC-C monolayer cultures and permeability measurements were performed as in Fig 3. HUV-EC-C monolayers were either left untreated (n = 4; ○) or were exposed to 10⁻⁸ mol/L DA7 (n = 6; •). Monolayer permeability was measured by TEFF and is expressed as the mean ± standard deviation. Statistically significant differences between the mean responses of treated and time-matched control monolayers are depicted as follows: *P < .05.