American Society of Hematology

Fig. 4.

$Fig. 4. Cycling activity of CAFC subsets in old and young mice. Shown is the fraction of CAFC day 7 (A), 14 (B), 21 (C), and 28 (D), obtained from young (•) or old (▴) mice, that were killed by incubation, in vitro, with hydroxyurea (HU). The regression line, using individual data points obtained in young and old mice, shows the relationship with the maximal lifespan of the respective strains. Lifespans for C3H/He is 500 days, for CBA/J 512 days, for DBA/2 710 days, for BALB/c 745 days, and for C57BL/6 789 days. The correlation coefficient “r” of these lines is given in each figure, in addition to the level of significance (p). CAFC day 35 were not affected by HU (data are not shown).$

Cycling activity of CAFC subsets in old and young mice. Shown is the fraction of CAFC day 7 (A), 14 (B), 21 (C), and 28 (D), obtained from young (•) or old (▴) mice, that were killed by incubation, in vitro, with hydroxyurea (HU). The regression line, using individual data points obtained in young and old mice, shows the relationship with the maximal lifespan of the respective strains. Lifespans for C3H/He is 500 days, for CBA/J 512 days, for DBA/2 710 days, for BALB/c 745 days, and for C57BL/6 789 days. The correlation coefficient “r” of these lines is given in each figure, in addition to the level of significance (p). CAFC day 35 were not affected by HU (data are not shown).

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