Fig. 5.
Immuno-EM of RBC membrane skeletons using the surface replica method with antihuman ankyrin rabbit polyclonal IgG antibody. Marked aggregation of ankyrin was observed in the 4.1 (−) Madrid case ([B] n = 1, obs 10) as compared with normal subjects ([A] n = 20, obs 50). Original magnification × 100,000. Bars indicate 0.1 μm.