To assess the effect of long-term anti-D treatment on HIV disease progression, serial CD4 counts were retrospectively evaluated in all 18 HIV⁺ patients who received more than two anti-D infusions per year, had two or more CD4 measurements per year, and were observed for a minimum of 2 years after starting anti-D therapy. The two most heavily treated patients are shown. The y-axis represents the percentage of CD4 and the x-axis the time (days). The arrows illustrate the anti-D infusions. Least square analysis of the change of CD4 percentage over time is presented. (Upper panel) A 33-year-old woman with HIV-related thrombocytopenia, who received 145 infusions of anti-D over 5 years and had a change of +2.7/yr in her CD4 percentage, ie, a total increase of 13.5%. (Lower panel) An HIV⁺ child with hemophilia who started anti-D treatment at 9 years of age and received 95 infusions over 8 years showed a change of +0.65/yr in the CD4 percentage, ie, a total increase of 5.2%.