Erythrocytes from HSA-deficient mice show increased aggregation. (A) The forward (FSC) light scattering of blood erythrocytes is shown for wild-type (HSA+, dotted line) and HSA-deficient (HSA-, thick line) mice at a flow rate of 130 events/s (sample differential 0.5). Increasing the flow rate to 600 events/s (sample differential 3.0) results in disaggregation of the HSA- erythrocytes (thin solid line). (B) The average blood sedimentation distance, with standard deviations, from five wild-type (+/+) and five HSA-deficient (-/-) mice over time is shown.