Mean (±SEM) plasma concentrations of t-PA (A), PAP complexes (B), and D-dimer (C) after endotoxin administration (4 ng/kg) in humans. Placebo (○) or rhIL-10 (25 μg/kg IV, •) was given just before endotoxin challenge (group 1) or 1 hour after endotoxin administration (group 2). P values indicate differences between treatment groups.