Cytotoxic granule antigen expression in a common form of ALCL (Table 2; case 11). (A) Immunostain for CD30 highlights sheets of large tumor cells. (B) The tumor cells of this case display granular cytoplasmic TIA-1 immunoreaction with paranuclear accumulation in the Golgi region. (C) Strong cytoplasmic perforin reaction is shown in the same case. (sABC-peroxidase technique, hematoxylin counterstain, original magnification × 400.)