BCL1 breakpoints. (A) Partial restriction map of the BCL1 locus illustrating cosmid and probe locations and breakpoints cloned in this study. Breakpoint of Granta 519 marked with its derived probe (p519ES, a 500-bp EcoRI/Sac I fragment). Note that this breakpoint falls within a window not covered by other probes. Map taken from Williams et al40 and Raynaud et al.41 (B) Sequences of breakpoints cloned in cases with t(11; 14); JH sequences are underlined and JH segment involved in breakpoint is shown. Bold type refers to Alu repeats. B, BamHI; E, EcoRI; H, HindIII; S, Sac I.