Intraclonal heterogeneity of lymphoma V genes. The four VL and 10 VH clones sequenced from case HA are shown in (A) and (B), respectively, compared with the proposed germline genes. VH clones HC6, HC8, HC9, and HC10 were isolated from the lymph node specimen, while the others were derived from the parotid gland specimen. Replacement mutations are in upper case, while silent mutations are in lower case. Mutations not common to all of the VH or VL sequences are bolded and also listed in Table 4 along with similar mutations identified in the other lymphoma V genes. Individual clones referred to in the text are prefixed with the identifying patient letters, eg, HAHC10 refers to clone HC10 from patient HA.