Segregation patterns of the P626A/G and S460P polymorphisms in the PROS1 gene in families PS6, PS229, and PS10, indicating absence of cosegregation between the P or PS Heerlen allele of S460P and type III PS deficiency in families PS6 and PS229 and absence of linkage in family PS10. (╞, ◑) Heterozygosis for type III PS deficiency; (, ) not tested; (□, ○) deceased; (↗) propositus; T, thrombotic disease. Individual values for total PS antigen, free PS antigen, and PS activity are expressed as the percentage of normal and from left to right, respectively, below the corresponding symbol. ND, not determined. S or P are the serine or proline alleles at codon 460; A or G are the alleles for adenine or guanine at codon for proline 626.