Segregation patterns in families PS6 and PS10 of four microsatellites closely linked to the C4BPB and C4BPA genes, indicating no linkage between these genes and type III PS deficiency. (╞, ◑) Heterozygosis for type III PS deficiency; (, ) not tested; (□, ○) deceased; (↗) propositus; T, thrombotic disease. The genotype of each individual for these microsatellites is indicated below each symbol as basepair fragments for the RCA5, C4BPB, RCA8, and REN alleles, from top to bottom, respectively. The corresponding haplotype, in lowercase letters, is indicated below. Haplotypes between parentheses are the inferred ones.