mRNA levels of lmp2 in B cells are significantly reduced after incubation with viral IL-10 (vIL-10), cellular IL-10 (hIL-10), or B95.8 supernatants containing IL-10 (B95.8) in comparison to cells that had been incubated with RPMI only. hIL-10 seems to have the most dramatic effect on the reduction of lmp2 expression.