Fig. 6.
Fig. 6. Recovery of mature cells and progenitors after 5-FU–induced cytotoxicity and recovery of platelets after immune thrombocytopenia. Kinetics of recovery of white blood cells (WBC; A), platelets (B), and myeloid progenitors (C) after a single administration of 5-FU. The figure represents the mean ± SD of WBC and platelet numbers of IL11Ra+/+ (n = 6) and IL11Ra−/− (n = 5) mice after 150 mg/kg 5-FU (intraperitoneal). Granulocyte-macrophage colony number (mean ± SD) of replicate cultures from 3 mice of each genotype on days 2, 4, and 6 after 150 mg/kg 5-FU (intravenous) is also shown (C). Cultures contained 50,000 bone marrow cells stimulated with final concentrations of GM-CSF at 10 ng/mL, IL-3 at 10 ng/mL, IL-6 at 100 ng/mL, and SCF at 100 ng/mL. (D) Kinetics of recovery of platelets after a single intraperitoneal administration of antiplatelet serum. The figure represents the mean ± SD of platelet numbers (n = 5 IL11Ra+/+ mice; n = 6 IL11Ra−/− mice).

Recovery of mature cells and progenitors after 5-FU–induced cytotoxicity and recovery of platelets after immune thrombocytopenia. Kinetics of recovery of white blood cells (WBC; A), platelets (B), and myeloid progenitors (C) after a single administration of 5-FU. The figure represents the mean ± SD of WBC and platelet numbers of IL11Ra+/+ (n = 6) and IL11Ra−/− (n = 5) mice after 150 mg/kg 5-FU (intraperitoneal). Granulocyte-macrophage colony number (mean ± SD) of replicate cultures from 3 mice of each genotype on days 2, 4, and 6 after 150 mg/kg 5-FU (intravenous) is also shown (C). Cultures contained 50,000 bone marrow cells stimulated with final concentrations of GM-CSF at 10 ng/mL, IL-3 at 10 ng/mL, IL-6 at 100 ng/mL, and SCF at 100 ng/mL. (D) Kinetics of recovery of platelets after a single intraperitoneal administration of antiplatelet serum. The figure represents the mean ± SD of platelet numbers (n = 5 IL11Ra+/+ mice; n = 6 IL11Ra−/− mice).

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