Ultrastructural examination of CD34-derived apoptotic megakaryocytes. (A) shows an apoptotic nucleus (n) surrounded by a short rim of cytoplasm (c) in continuity with a portion of granulated (arrows) cytoplasm. OM × 8,000. (B) shows a late apoptotic nucleus (n) surrounded by granulated cytoplasm. Also note that the apoptotic nucleus is in close proximity to a normal megakaryocyte (*) showing the typical dense core granules. OM × 6,000. Inset shows a higher magnification of dense core granules (OM × 60,000). (C) shows an apoptotic micronucleus (n) with the characteristic chromatin cap (*) and cytoplasmic remnants (r) in proximity to a mature platelet (p). OM × 8,000.