Fig. 2.
As2O3 induces morphological changes in cultured primary APL cells and NB4 cells. (A through D): NB4 cells were treated without (A) and with 1 μmol/L (B) As2O3 for 24 hours, and 0.5 (C) and 0.1 μmol/L (D) As2O3 for 10 days; (E and F): BM cells from one relapsed APL patient were cultured and treated in vitro without (E) and with (F ) 2 μmol/L As2O3 for 24 hours. Similar results were also observed in three other APL cases. Cells were centrifuged onto slides by cytospin (Shandon, 500 rpm, 4 minutes) and stained with Wright's staining.
