Fig. 4.
(A) CTL line T15 mediates an apparent three log reduction of leukemia in an autologous BMT model. C57Bl/6 mice were irradiated with 800 cGy TBI and transplanted with 5 × 106 syngeneic BM and received graded doses of C1498 leukemia cells IV on day 0. Two groups received T15 CD8+ CTL cells 107 IV on days 1, 8, and 15. (B) Persistence of adoptively transferred T15 CTLs. Mice surviving until day 70 following 2 × 105 C1498 leukemia and receiving T15 107 cells on days 1, 8, and 15 were rechallenged with 2 × 105 C1498 leukemia. Control mice had received syngeneic BMT 70 days before challenge with 2 × 105 C1498 leukemia.
