IL-15–induced cytokine production by T cells. (A) T cells were isolated by rosetting and then stimulated as indicated. After 72 hours cell-free supernatants were procured and assayed for IFN-γ. Depicted are mean and SEM of six independent experiments. Significantly altered cytokine production induced by anti-CD3 + IL-15 (⋄) or IL-2 (♦) compared to anti-CD3 alone (248 ± 58 pg/mL) is indicated by * (P < .01) or ** (P < .05). (B) T cells were isolated by rosetting and then stimulated as indicated. After 72 hours cell-free supernatants were procured and assayed for TNF-α. Depicted are mean and SEM of six independent experiments. Significantly altered cytokine production induced by anti-CD3 + IL-15 (□) or IL-2 (▪) compared to anti-CD3 alone (65 ± 9 pg/mL) is indicated by * (P < .01) or ** (P < .05). (C) T cells were isolated by rosetting and then stimulated as indicated. After 72 hours cell-free supernatants were procured and assayed for IL-10. Depicted are mean and SEM of six independent experiments. Significantly altered cytokine production induced by anti-CD3 + IL-15 (▵) or IL-2 (▴) compared to anti-CD3 alone (2.5 ± 1.6 pg/mL) is indicated by * (P < .01) or ** (P < .05).