Interactive effects of cytokines and iron on the secretion of ferritin (A) and albumin (B) by hepatoma cells. Bars indicate mean amounts of ferritin and albumin in the medium, per milligram of hepatoma cell protein, as a percent of that for control (untreated) cells, after 48 hours incubation. Doses were 5.0 ng/mL IL-1, 2.5 ng/mL TNF, and 10 μg/mL Fe-NTA. Mean values ± SD are for three flasks in the case of treated cells, and six flasks in the case of controls. All differences from the values for controls were significant (P < .01) except in the case of albumin from cells treated only with TNF.