Fig. 1.
Schematic representation of the study design. PD, persistent disease; CR, complete remission. Induction 1: daunorubicin 45 mg/m2 (3 days), cytosine-arabinoside 200 mg/m2 (7 days), and etoposide 100 mg/m2 (5 days). Induction 2: daunorubicin 45 mg/m2 (2 days), cytosine-arabinoside 200 mg/m2 (5 days), and etoposide 100 mg/m2 (5 days). Consolidation 1: daunorubicin 45 mg/m2 (2 days), cytosine-arabinoside 200 mg/m2 (5 days), and etoposide 100 mg/m2 (5 days). Consolidation 2: (optional) <50 years: cytosine-arabinoside 3 g/m2 12 hourly (6 days), daunorubicin 30 mg/m2 (2 days); ≥50 years: daunorubicin 45 mg/m2 (2 days), cytosine-arabinoside 200 mg/m2 (5 days), and etoposide 100 mg/m2 (5 days).
