Fig. 7.
Fig. 7. TNF-α–stimulated adhesion of HL60 cells to HCMEC is inhibited by neuraminidase but not by NaClO3 . At 2.4 dyne/cm2, adhesion of HL60 cells to activated HCMEC is reduced by anti–E-selectin MoAb BBA2 to the level of adhesion on nonactivated HCMEC. E-selectin dependent adhesion is inhibited by neuraminidase digestion of sLex from the HL60 cell surface. Cultivation of HCMEC in the presence of NaClO3 shows no effect on the adhesion behavior. Mean values ±SEM; *P < .05 versus positive control.

TNF-α–stimulated adhesion of HL60 cells to HCMEC is inhibited by neuraminidase but not by NaClO3 . At 2.4 dyne/cm2, adhesion of HL60 cells to activated HCMEC is reduced by anti–E-selectin MoAb BBA2 to the level of adhesion on nonactivated HCMEC. E-selectin dependent adhesion is inhibited by neuraminidase digestion of sLex from the HL60 cell surface. Cultivation of HCMEC in the presence of NaClO3 shows no effect on the adhesion behavior. Mean values ±SEM; *P < .05 versus positive control.

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