American Society of Hematology

Fig. 1.

$Fig. 1. The effect of unfractionated heparin and the LMWH, Tinzaparin, on the excretion of urinary pyridinoline. Rats were injected with vehicle alone; unfractionated heparin at a concentration of 0.5 U/g (▵) or 1.0 U/g (•), or the LMWH, Tinzaparin, at a concentration of 0.5 U/g (▴) or 1.0 U/g (□), and the excretion of pyridinoline determined. To account for variations in urine concentration, results are calculated in terms of nmol/mL of urinary creatinine. Values are expressed as a percentage of the controls at either days 0, 4, 8, 16, or 32. Control values routinely varied between 400 and 200 nmol/L PYD/mmol/L creatinine. P < .01 when compared with control values.$

The effect of unfractionated heparin and the LMWH, Tinzaparin, on the excretion of urinary pyridinoline. Rats were injected with vehicle alone; unfractionated heparin at a concentration of 0.5 U/g (▵) or 1.0 U/g (•), or the LMWH, Tinzaparin, at a concentration of 0.5 U/g (▴) or 1.0 U/g (□), and the excretion of pyridinoline determined. To account for variations in urine concentration, results are calculated in terms of nmol/mL of urinary creatinine. Values are expressed as a percentage of the controls at either days 0, 4, 8, 16, or 32. Control values routinely varied between 400 and 200 nmol/L PYD/mmol/L creatinine. P < .01 when compared with control values.

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