Changes in white blood cells (- -) and in circulating clonogenic progenitors (CFU-C/mL blood) in nonhuman primates treated with combinations of G-CSF and KL. In panel A, results from four animals treated with G-CSF (100 μg/kg/d for 5 days) and KL (25 μg/kg/d for 5 days) are shown. (Pretreatment and day-5 values were available from all four animals and only these values have error bars.) One animal (B) was treated with the same dose of G-CSF but with KL 100 μg/kg/d for 5 days. The animal in panel C was given anti-VLA4 antibody (1 mg/kg/d) for 2 days after G-CSF plus KL treatment (like animal A in Fig 2), whereas the animal in panel D was given G-CSF plus KL (like animal A) but for the first 3 days of treatment was also given anti-VLA4.