Absence of E- and P-selectin on cerebral vessel endothelium during EAE in SJL/J mice. An inflammatory cuff in the spinal cord of a SJL/J mouse afflicted with acute EAE (day 14, clinical score +++) is shown. CD31/PECAM-1 is expressed by all cerebral endothelial cells. E- and P-selectin cannot be detected. ⊘; isotype matched control. Immunoperoxidase staining, hematoxylin counterstain; original magnification × 240.