Peripheral thrombi in the jaundiced and spherocytic mice can cause degeneration of BM and muscle in hind limbs. Bouin's-fixed, paraffin-embedded sections of hind limbs stained with H&E are shown. (a) ja/ja mouse #43 with probable thrombus at aortic bifurcation 3.25 months, (b) +/+ nonlittermate control 6 months old. B, bone marrow; M, muscle.