Genomic analysis of the t(11; 22)(q23; q13) chromosome translocation. (A) Physical map of the t(11; 22) junction in the patient, as well as the corresponding regions from chromosomes 11 and 22. (B) Sequence of the t(11; 22) breakpoint region in the patient. Cen and Tel denote the direction of the centromeres and telomeres of the two chromosomes. Open vertical boxes represent defined exons. Restriction sites: B, BamHI. kb, kilobase.