Fig. 6.
Peptide inhibition of increased adherence of calcium-loaded normal red blood cells. Red blood cells were loaded with 10 μmol/L calcium using the ionophore A23187. The increased adherence of calcium-loaded cells above that of control cells is defined as abnormal adherence and is arbitrarily normalized in the first bar. Shown in the following bars are the relative effects on this abnormal adherence of peptides 2f, 3d-L, and 3dS at 10, 25, and 42 μg/mL, respectively. Error bars represent corresponding standard deviations for the number of experiments indicated in the parentheses and asterisks indicate statistical significance at P < .05 (see Materials and Methods).