Homology between the human and avian β3 genes. (A) Schematic representation showing the homologous regions of the 5′ regions of the human and avian β3 genes. Sequences were compared as described in the Materials and Methods. A1 refers to exon 1 of the avian gene.25 Nucleotide positions are relative to the transcription start sites. The numbers between the horizontal lines refer to the percentage of homology between regions H1, H2, and H3 of each gene. B, Bsm I; H, HindIII; X, Xba I; E, EcoRI; S, Sac I. In (B) through (E), the human and avian sequence numbering is according to the GenBank entry. (B) Alignment of the H1 region of the human and avian β3 genes. The thick underline indicates the VDRE of the avian gene. (C) Alignment between the avian VDRE with the corresponding human sequence from the H2 region. Dot matrix plots of the H1 (D) and H2 (E) regions of the human and avian β3 genes.
