Dose-response relation (A) and time course (B) of ¹¹¹In-eosinophil accumulation induced by intradermal TNFα in rat skin. Animals were injected IV with ¹¹¹In-eosinophils. (A) TNFα (•) or Tyrode solution (○) was injected ID into the previously clipped back skin of rats and responses measured over a 4-hour period. (B) TNFα (10⁻¹¹ mol/site; •) or Tyrode solution (○) was injected ID at different time points within a 4-hour period. Responses are the mean ± SEM for n = 4 to 6 rats. A significant difference from the 4-hour Tyrode level is indicated by *P < .05 or **P < .01.