Immunohistology shows LMP2A expression in HRS cells of a case of mixed cellularity HD using the MoAbs 4E11 (A) and 15F9 (B). Double-labeling shows colocalization of the LMP2A-specific signal (red membrane staining) and the EBER in situ hybridization product (blue/black nuclear staining) in HRS cells of the same case (C). Immunohistology with the MoAb 15F9 shows expression of LMP2A in numerous extrafollicular lymphoid blasts in a tonsil from a patient with acute IM (D).