Fig. 1.
Fig. 1. CD4 ligation with gp160 or CD4XL with gp160 and anti-gp160 induces tyrosine phosphorylation of various cellular substrates: CD4+ T cells were treated with gp160 alone or with gp160 plus anti-gp160. Cell lysates were precleared and immunoprecipitated with antibodies to substrates p56lck, p59fyn, ZAP-70, PLC-γ1 (145 kD), and p95vav as indicated and immunoblotted with either the specific antibody or with antiphosphotyrosine antibody (4G10).

CD4 ligation with gp160 or CD4XL with gp160 and anti-gp160 induces tyrosine phosphorylation of various cellular substrates: CD4+ T cells were treated with gp160 alone or with gp160 plus anti-gp160. Cell lysates were precleared and immunoprecipitated with antibodies to substrates p56lck, p59fyn, ZAP-70, PLC-γ1 (145 kD), and p95vav as indicated and immunoblotted with either the specific antibody or with antiphosphotyrosine antibody (4G10).

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