Influence of pretreatment with SDZ MRL 953 on the endotoxin-induced release of proinflammatory cytokines in cancer patients. Serum concentrations of (A) TNF-α, (B) IL-1β, (C) IL-8, and (D) IL-6 in patients after an intravenous bolus injection of LPS (2 ng/kg) administered 72 hours after the last of seven injections of (•) SDZ MRL 953 (18.0 to 39.6 μg/kg, n = 14) or (▿) vehicle control (n = 5). Data are expressed as the mean ± SEM. *P < .05 between groups.