Fig. 5.
Influence of pretreatment with SDZ MRL 953 on the endotoxin-induced release of G-CSF and changes in neutrophil counts in cancer patients. (A) Serum levels of G-CSF and (B) percentage changes of neutrophil granulocytes in patients after an intravenous bolus injection of LPS (2 ng/kg) administered 72 hours after the last of seven injections of (•) SDZ MRL 953 (18.0 to 39.6 μg/kg, n = 14 [A] and n = 10 [B]) or (▿) vehicle control (n = 5). Data are expressed as the mean ± SEM. *P < .05, **P < .01 between groups.