Fig. 2.
Persistence of virus-specific CTL responses in the spleen and bone marrow. At 325 days postinfection, LCMV-immune mice were euthanized, and spleen and bone marrow cells were stimulated in vitro with virus for 5 days. Following stimulation, the antiviral CTL activity of spleen and bone marrow samples was determined by measuring specific 51Cr release from the lysis of LCMV-infected targets. Data represent the mean ±SD of 4 mice. Lysis of LCMV-infected targets is shown with closed symbols and lysis of uninfected targets is shown with open symbols at the indicated E:T ratios.
