Fig. 6.
![Fig. 6. The effects of FcγRI antagonists on rhIFN-γ–enhanced bacterial ingestion by neutrophils. The graph shows the effect of anti-FcγRI MoAb (197) and F(ab′)2 (32.2), and control murine IgG2a (mIgG2a) and murine F(ab′)2 [mF(ab′)2 ] on phagocytosis of HI-PHS–opsonized S aureus-BODIPY BioParticles by neutrophils. The mean MFI of neutrophils obtained from two different study subjects (□) before in vivo rhIFN-γ administration (0.05 mg/m2/dose SC daily for 2 days) and (▪) 48 hours after the initiation of in vivo rhIFN-γ treatment are depicted. Asterisks indicate statistically significant inhibition by the MoAb or F(ab′)2 when compared with the corresponding 48-hour control in which no MoAb or F(ab′)2 was present (Student's t-test, P < .05).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/90/8/10.1182_blood.v90.8.3187/4/bl_0003f6.jpeg?Expires=1735572719&Signature=Byamw9vFwL0PaX3cDnrnmblzH0M4gQEtmqAzawxB3XKGeg-dOLpV41GM8bfG~L1T7txED0RCSbIfZJT~XgYzcrzHJX5Mzd2zXz3hNVebXRHdWhpC9okHozU6sjq895dQS8y4dTXLXhgC7987wffJXkChb4IelqGr1SV6mViMP5wn8IQ0Efw~XCdxWbYjLVNIcWULef0BP4IpQ4ZXXtgohheR7pnM7EqjxvnOpVoNQyraUnErH-knMknQdI8cW8MvDIKJmwJFyncPR~JnLwwU3v~PUXyAV3aZpMylY3zgC2BbwMfA3SRSTF2Az2Qn16FzEqdxvEzwy-7f~ozzJvGsTw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The effects of FcγRI antagonists on rhIFN-γ–enhanced bacterial ingestion by neutrophils. The graph shows the effect of anti-FcγRI MoAb (197) and F(ab′)2 (32.2), and control murine IgG2a (mIgG2a) and murine F(ab′)2 [mF(ab′)2 ] on phagocytosis of HI-PHS–opsonized S aureus-BODIPY BioParticles by neutrophils. The mean MFI of neutrophils obtained from two different study subjects (□) before in vivo rhIFN-γ administration (0.05 mg/m2/dose SC daily for 2 days) and (▪) 48 hours after the initiation of in vivo rhIFN-γ treatment are depicted. Asterisks indicate statistically significant inhibition by the MoAb or F(ab′)2 when compared with the corresponding 48-hour control in which no MoAb or F(ab′)2 was present (Student's t-test, P < .05).
