Fig. 5.
Antibodies against IFN-γ abrogate rmIL-12–induced toxicity. C3H/Hej mice were injected subcutaneously with rmIL-12 (0.5 μg) for 6 consecutive days. Anti-IFN–γ antibody (XMG1.2, •) or an isotype control (□) was administered by intraperitoneal injection on days 0 to 5 at a dose of 250 μg per mouse (n = 4). (♦), Rat IgG.