(A) The ABC1 blockers, DIDS and BSP, inhibit the secretion of IL-1β in a dose-dependent fashion. Results are expressed as a percentage of the secretion from untreated macrophage monolayers. Absolute amounts (average from 4 individual points) of IL-1β in picograms per milliliter are reported. (B) Comparative effect of DIDS and BSP on the secretion of IL-1β, IL-1α, TNFα, or IL-6. Results (averaged from 6 experiments for IL-1β and TNFα and from 4 for IL-1α and IL-6) are expressed as a percentage of the amount released in the absence of drug.