Fig. 1.
Effect of immobilized Lym-2 on the proliferation of various B-cell lymphoma cell lines. Lymphoma cell lines were incubated with Lym-2 or mIgG1 with immobilization by prior coating plates by goat-antimouse IgG1. Three days later, effects on growth were evaluated by incorporation of [3H]-thymidine. Soluble Lym-2 exerted no effect on proliferation of these lymphoma cell lines (data not shown). However, immobilized Lym-2 significantly inhibited the proliferation of (A) RL, (B) TU-2C, (C) Raji, (D) Michel, (E) Daudi, and (F ) DB cell lines (P < .05) with optimal inhibition of thymidine incorporation (39% to 65%) occurring at 1 μg/mL of Lym-2.