Comparison of pulmonary plasma clot lysis in mice injected with wild type versus inhibitor-resistant t-PA-expressing adenoviruses. Clot lysis experiments were performed 4 days after gene transfer. The residual radioactivity in clots was measured after 4 hours of lysis. Values represent mean ± SEM of the indicated number of mice in parentheses. *P < .05 v lysis in uninjected mice (none) of the same genotype. (A) Clot lysis in t-PA^−/− mice. (B) Wild type (shaded bars) and PAI-1–overexpressing transgenic mice (solid bars) were injected intravenously with 5 × 10⁸ pfu recombinant viruses AdCMVt-PA^WT and AdCMVt-PA^CB.