Partial metaphases hybridized with biotin-labeled cubilin cDNA, showing (a) the specific FISH signals on the homologous chromosome 10p-regions (arrows) superimposed on the DAPI-stained chromosomes, (b and c) FISH signals on more elongated chromosomes, and (d) a chromosome ideogram31 showing the localization of the intrinsic factor receptor gene and the mean FLpter value (arrow). The box indicates the variation in Flpter values on individual chromosomes.