Fig. 5.
Fig. 5. Model of systemic AIDS-NHL histogenesis. The proposed model is based on the expression pattern of BCL-6 and CD138/syndecan-1 (syn-1) throughout physiologic B-cell differentiation. B cells within the germinal center (GC) display the BCL-6+/syn-1− phenotype, whereas B cells that have exited the GC and have undergone further maturation toward the plasma cell stage exhibit the BCL-6−/syn-1+ phenotype. On these bases, systemic AIDS-NHL displaying the BCL-6+/syn-1− phenotype, ie, AIDS-SNCCL and AIDS-LNCCL, are postulated to originate from GC B cells. Conversely, systemic AIDS-NHL displaying the BCL-6−/syn-1+ phenotype, ie, AIDS-IBLP, are postulated to derive from preterminally differentiated B cells. In the case of AIDS-NHL infected by EBV, the BCL-6−/syn-1+ phenotype is permissive for expression of the EBV encoded LMP-1 antigen. Conversely, LMP-1 expression is consistently absent among AIDS-NHL displaying the BCL-6+/syn-1− phenotype.

Model of systemic AIDS-NHL histogenesis. The proposed model is based on the expression pattern of BCL-6 and CD138/syndecan-1 (syn-1) throughout physiologic B-cell differentiation. B cells within the germinal center (GC) display the BCL-6+/syn-1− phenotype, whereas B cells that have exited the GC and have undergone further maturation toward the plasma cell stage exhibit the BCL-6−/syn-1+ phenotype. On these bases, systemic AIDS-NHL displaying the BCL-6+/syn-1− phenotype, ie, AIDS-SNCCL and AIDS-LNCCL, are postulated to originate from GC B cells. Conversely, systemic AIDS-NHL displaying the BCL-6−/syn-1+ phenotype, ie, AIDS-IBLP, are postulated to derive from preterminally differentiated B cells. In the case of AIDS-NHL infected by EBV, the BCL-6−/syn-1+ phenotype is permissive for expression of the EBV encoded LMP-1 antigen. Conversely, LMP-1 expression is consistently absent among AIDS-NHL displaying the BCL-6+/syn-1− phenotype.

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